How mtDNA mutations cause aging
نویسندگان
چکیده
منابع مشابه
Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production.
The mitochondrial theory of aging proposes that reactive oxygen species (ROS) generated inside the cell will lead, with time, to increasing amounts of oxidative damage to various cell components. The main site for ROS production is the respiratory chain inside the mitochondria and accumulation of mtDNA mutations, and impaired respiratory chain function have been associated with degenerative dis...
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Aging is a complex biological process that involves gradual function deterioration in various tissues and organs of an individual. Mitochondrial function decline can lead to cellular overproduction of reactive oxygen species (ROS) and increase in oxidative damage to biological molecules in the aging process. We have hypothesized that increased production of ROS by the mitochondria in affected t...
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Mitochondria play a critical role in the life of the cell as they control their metabolic rate, energy production and cell death. Mitochondria have long been appreciated as causative to aging. The age-associated respiratory chain deficiency is typically unevenly distributed and affects only a subset of cells in various human tissues, such as heart, skeletal muscle, colonic crypts and neurons. S...
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Aging is a universal, lifelong and inevitable phenomenon, the product of an interaction between genetic, environmental and lifestyle factors. The biological changes that occur during the aging process affect virtually all components of living systems, from the molecular up to that of the whole organism. These changes lead to a breakdown in the normal homoeostatic mechanisms, and so the function...
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ژورنال
عنوان ژورنال: Genome Biology
سال: 2004
ISSN: 1465-6906
DOI: 10.1186/gb-spotlight-20050718-01